️成分名：コラーゲンペプチド
原料：天然タラ魚皮由来
配合量 ：8000 mg
原産地/原料加工地：カナダ
原料メーカー：Kenney&Ross Limited
製造品質管理水準：CFIA基準準拠
（日本ゼラチン・コラーゲン工業組合 食用コラーゲンペプチド規格、
GMPおよびHACCP規格と同等の運用）
わたしたちの扱うコラーゲンペプチドの特徴として、以下の項目が挙げられます。
◽️吸収力が高い低分子コラーゲンペプチド
◽️安心・安全の天然魚皮由来
◽️世界髄一の環境国家であるカナダ生育魚
◽️抗生物質、ワクチン未使用
◽️防腐剤、添加物未使用
◽️重金属未含有
◽️超高純度抽出法採用（加水分解法）
◽️安全性テスト（CFIA基準準拠）合格
◽️アレルギー物質0.02PPM以下
環境大国カナダの東海岸『ノバスコシア州』
古くから漁業が盛んで栄えるこの地では水質、環境ともに抜群であり最高のコラーゲン産生地と言えます。
Kenney& Ross Limitedは1945年創業、それ以来この最高の立地で魚専門のコラーゲンを製造しています。
カナダでは食の安全に注力しており安全検査には日本よりも遥かに厳しい基準を採用しています。
毎ロットごとに製品分析を行い、重金属を10ppm未満と厳格に管理し、ヒ素、水銀、カドミウムなどを測定しているメーカーはKenney& Ross Limitedのみです。
またアレルギー検査に関しても、主要アレルゲンである『パルブアルブミン0.02ppm以下とういう厳格な基準を設定しています。
成分に関する約19,000件の論文のうち、重要な論文についてここに掲載します。
論文は✔Double Blind Test ✔RCT ✔Systematic Review を中心にスクリーニングしています。
| Oral collagen-derived dipeptides, prolyl-hydroxyproline and hydroxyprolyl-glycine, ameliorate skin barrier dysfunction and alter gene expression profiles in the skin | 2015 |
Shimizu J, Asami N, Kataoka A, et al. Biochem Biophys Res Commun. 2015;456(2):626-630. doi:10.1016/j.bbrc.2014.12.006 |
| Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts | 2010 |
Ohara H, Ichikawa S, Matsumoto H, et al. J Dermatol. 2010;37(4):330-338. doi:10.1111/j.1346-8138.2010.00827. |
| Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity | 2011 |
Zague V, de Freitas V, da Costa Rosa M, de Castro GÁ, Jaeger RG, Machado-Santelli GM. J Med Food. 2011;14(6):618-624. doi:10.1089/jmf.2010.0085 |
| Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis | 2006 |
Matsuda N, Koyama Y, Hosaka Y, et al. J Nutr Sci Vitaminol (Tokyo). 2006;52(3):211-215. doi:10.3177/jnsv.52.211 |
| Collagenolytic cleavage products of collagen type I as chemoattractants for human dermal fibroblasts | 1985 |
Albini A, Adelmann-Grill BC. Collagenolytic cleavage products of collagen type I as chemoattractants for human dermal fibroblasts. Eur J Cell Biol. 1985;36(1):104-107. |
| Effect of Prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin | 2009 |
Shigemura Y, Iwai K, Morimatsu F, et al. J Agric Food Chem. 2009;57(2):444-449. doi:10.1021/jf802785h |
| Collagen: A review on its sources and potential cosmetic applications. | 2018 |
Avila Rodríguez MI, Rodríguez Barroso LG, Sánchez ML. Collagen: 2018;17(1):20-26. doi:10.1111/jocd.12450 |
| Clinical effects of fish type I collagen hydrolysate on skin properties | 2006 |
MATSUMOTO H, ITE Letters 7, 386-390, 2006 |
| Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis | 2014 |
Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Skin Pharmacol Physiol. 2014;27(1):47-55. doi:10.1159/000351376 |
|
Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. |
2015 |
Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Skin Pharmacol Physiol. 2014;27(1):47-55. doi:10.1159/000351376 |
| Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails | 2017 | Hexsel D, Zague V, Schunck M, Siega C, Camozzato FO, Oesser S. J Cosmet Dermatol. 2017;16(4):520-526. doi:10.1111/jocd.12393 |
| The collagen family | 2011 |
Ricard-BlumS. 2011;3(1):a004978. Published 2011 Jan 1. doi:10.1101/cshperspect.a004978 |
| Skin aging and oxidative stress: Equol's anti-aging effects via biochemical and molecular mechanisms | 2016 |
Lephart ED. Ageing Res Rev. 2016;31:36-54. doi:10.1016/j.arr.2016.08.001 |
| Collagen: A review on its sources and potential cosmetic applications | 2018 |
Avila Rodríguez MI, Rodríguez Barroso LG, Sánchez ML. J Cosmet Dermatol. 2018;17(1):20-26. doi:10.1111/jocd.12450 |
| Collagen and gelatin | 2015 |
Liu D, Nikoo M, Boran G, Zhou P, Regenstein JM. Annu Rev Food Sci Technol. 2015;6:527-557. doi:10.1146/annurev-food-031414-111800 |
| Collagen peptides modulate the metabolism of extracellular matrix by human dermal fibroblasts derived from sun-protected and sun-exposed body sites | 2018 |
Zague V, do Amaral JB, Rezende Teixeira P, de Oliveira Niero EL, Lauand C, Machado-Santelli GM. Cell Biol Int. 2018;42(1):95-104. doi:10.1002/cbin.10872 |
| Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources | 2007 |
Ohara H,Matsumoto H, Ito K, Iwai K, Sato K. J Agric Food Chem. 2007;55(4):1532-1535. doi:10.1021/jf062834s |
| Daily consumption of the collagen supplement Pure Gold Collagen® reduces visible signs of aging | 2014 | Borumand M, Sibilla S. 2020 Feb 04;15:131]. Clin Interv Aging. 2014;9:1747-1758. Published 2014 Oct 13. doi:10.2147/CIA.S65939 |
| Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin | 2017 |
Yazaki M, Ito Y, Yamada M, et al. J Agric Food Chem. 2017;65(11):2315-2322. doi:10.1021/acs.jafc.6b05679 |
| Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis | 2006 |
Matsuda N, KoyamaY, Hosaka Y, et al. J Nutr Sci Vitaminol (Tokyo). 2006;52(3):211-215. doi:10.3177/jnsv.52.211 |
| Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin model | 2012 |
Okawa T, Yamaguchi Y, Takada S, et al. J Dermatol Sci. 2012;66(2):136-143. doi:10.1016/j.jdermsci.2012.02.004 |
| Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates | 2005 |
Iwai K, Hasegawa T, Taguchi Y, et al. J Agric Food Chem. 2005;53(16):6531-6536. doi:10.1021/jf050206p |
| Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study | 2014 | Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Skin Pharmacol Physiol. 2014;27(1):47-55. doi:10.1159/000351376 |
| Daily consumption of the collagen supplement Pure Gold Collagen® reduces visible signs of aging | 2014 |
Borumand M, Sibilla S. 2020 Feb 04;15:131]. Clin Interv Aging. 2014;9:1747-1758. Published 2014 Oct 13. doi:10.2147/CIA.S65939 |
| The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials | 2015 |
Asserin J,Lati E,Shioya T,Prawitt J. J Cosmet Dermatol. 2015;14(4):291-301. doi:10.1111/jocd.12174 |
| Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin | 2017 |
Yazaki M, Ito Y, Yamada M, et al. J Agric Food Chem. 2017;65(11):2315-2322. doi:10.1021/acs.jafc.6b05679 |
| Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails | 2017 |
Hexsel D, Zague V, Schunck M, Siega C, Camozzato FO, Oesser S. J Cosmet Dermatol. 2017;16(4):520-526. doi:10.1111/jocd.12393 |
| Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study | 2018 |
Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. 2018;10(7):826. Published 2018 Jun 26. doi:10.3390/nu10070826 |
| Skin ageing | 2011 |
Kohl E, Steinbauer J, Landthaler M, Szeimies RM. J Eur Acad Dermatol Venereol. 2011;25(8):873-884. doi:10.1111/j.1468-3083.2010.03963.x |
| Ingestion of BioCell Collagen(®), a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs | 2012 |
Schwartz SR, Park J. Clin Interv Aging. 2012;7:267-273. doi:10.2147/CIA.S32836 |
