成分名：Lオルニチン
原料：コメ、トウモロコシ
原産地：中国
原料加工地：日本
原料メーカー：プロテインケミカル株式会社
原料加工先の製造品質管理水準：GMP（Good Manufacturing Practice：食品添加物の製造管理及び品質管理の基準）準拠
わたしたちの扱うオルニチンの品質・安全管理にかかわる特徴は以下の項目が挙げられます。
◽️天然由来
◽️残有農薬検査済み
◽️防腐剤、添加物未使用
◽️安全性テスト施行済
成分に関する約17,000件の論文のうち、重要な論文についてここに掲載します。
論文はすべて ✔Double Blind Test ✔RCT ✔Systematic Review を満たしています。
| Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers | 2014 |
Miyake M, Kirisako T, Kokubo T, et al. Nutr J. 2014;13:53. Published 2014 Jun 3. doi:10.1186/1475-2891-13-53 |
| Effect of L-ornithine hydrochloride ingestion on intermittent maximal anaerobic cycle ergometer performance and fatigue recovery after exercise | 2011 |
Demura S, Morishita K, Yamada T, Yamaji S, Komatsu M. Eur J Appl Physiol. 2011;111(11):2837-2843. doi:10.1007/s00421-011-1896-1 |
| L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism | 2008 |
Sugino T, Shirai T, Kajimoto Y, Kajimoto O. Nutr Res. 2008;28(11):738-743. doi:10.1016/j.nutres.2008.08.008 |
| Simultaneous study of somatotrophic and corticotrophic pituitary secretions during ornithine infusion test | 1982 |
Evain-Brion D, Donnadieu M, Roger M, Job JC. 1982;17(2):119-122. doi:10.1111/j.1365-2265.1982.tb01571.x |
| Effect of supplemental ornithine on wound healing | 2002 | Shi HP, Fishel RS, Efron DT, Williams JZ, Fishel MH, Barbul A. J Surg Res. 2002;106(2):299-302. doi:10.1006/jsre.2002.6471 |
| Effects of Composite Supplement Containing Collagen Peptide and Ornithine on Skin Conditions and Plasma IGF-1 Levels-A Randomized, Double-Blind, Placebo-Controlled Trial | 2018 |
Ito N, Seki S, Ueda F. Mar Drugs. 2018;16(12):482. Published 2018 Dec 3. doi:10.3390/md16120482 |
| Healing effects of oral administration of L-citrulline or L-ornithine in a rat pressure-ulcer model ─Comparison with L-arginine─ | 2010 |
Mami Aoki PubMed |
| Ornithine ingestion and growth hormone release in bodybuilders | 1990 |
Luke Bucci, et al. Nutrition Research, Volume 10, Issue 3, March 1990, Pages 239-245 |
|
Oral administration of l-ornithine increases the content of both collagen constituting amino acids and polyamines in mouse skin. |
2019 |
Harada D, Nagamachi S, Aso K, Ikeda K, Takahashi Y, Furuse M. Biochem Biophys Res Commun. 2019;512(4):712-715. doi:10.1016/j.bbrc.2019.03.147 |
| Failure of commercial oral amino acid supplements to increase serum growth hormone concentrations in male body-builders. | 1993 |
Lambert MI, Hefer JA, Millar RP, Macfarlane PW. Int J Sport Nutr. 1993;3(3):298-305. doi:10.1123/ijsn.3.3.298 |
|
Efficacy and safety of ornithine alpha-ketoglutarate in heel pressure ulcers in elderly patients: results of a randomized controlled trial. |
2009 |
Meaume S, Kerihuel JC, Constans T, et al. J Nutr Health Aging. 2009;13(7):623-630. doi:10.1007/s12603-009-0173-z |
| Effect of a specialized amino acid mixture on human collagen deposition | 2002 |
Williams JZ, Abumrad N, Barbul A. 2002;236(3):369-375. doi:10.1097/00000658-200209000-00013 |
| Unusual effects of GH deficiency in adults: a review about the effects of GH on skin, sleep, and coagulation | 2014 |
Tanriverdi F, et al. PubMed |
| The IGF-1/IGF-1R signaling axis in the skin: a new role for the dermis in aging-associated skin cancer | 2010 |
Tanriverdi F, Karaca Z, Unluhizarci K, Kelestimur F. Endocrine. 2014;47(3):679-689. doi:10.1007/s12020-014-0276-0 |
|
The IGF-1/IGF-1R signaling axis in the skin: a new role for the dermis in aging-associated skin cancer. Oncogene. |
2010 |
Lewis DA, Travers JB, Somani AK, Spandau DF. 2010;29(10):1475-1485. doi:10.1038/onc.2009.440 |
| Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models | 2011 |
Schiaffino S, Mammucari C. 2011;1(1):4. Published 2011 Jan 24. doi:10.1186/2044-5040-1-4 |
| Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation | 2006 |
Sadagurski M, Yakar S, Weingarten G, et al. Mol Cell Biol. 2006;26(7):2675-2687. doi:10.1128/MCB.26.7.2675-2687.2006 |
| IGF-1 regulation of key signaling pathways in bone | 2013 |
Guntur AR, Rosen CJ. 2013;2:437. Published 2013 Oct 2. doi:10.1038/bonekey.2013.171 |
| Insulin-like growth factor 1 (IGF-1): a growth hormone | 2001 |
Laron Z Mol Pathol. 2001;54(5):311-316. doi:10.1136/mp.54.5.311 |
| Postglucose growth hormone nadir and insulin-like growth factor-1 in naïve-active acromegalic patients: do these parameters always correlate? | 2011 |
Ribeiro-Oliveira A Jr, Faje A, Barkan A. Arq Bras Endocrinol Metabol. 2011;55(7):494-497. doi:10.1590/s0004-27302011000700011 |
| Physiology of growth hormone secretion during sleep | 1996 |
Van Cauter E, Plat L. J Pediatr. 1996;128(5 Pt 2):S32-S37. doi:10.1016/s0022-3476(96)70008-2 |
| Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies | 2012 | Sonntag WE, Csiszar A, deCabo R, Ferrucci L, Ungvari Z. J Gerontol A Biol Sci Med Sci. 2012;67(6):587-598. doi:10.1093/gerona/gls115 |
| Growth hormone and aging: a challenging controversy | 2008 |
Bartke A. 2008;3(4):659-665. doi:10.2147/cia.s3697 |
